Background: In recent years there has been a trend of leaving the strict molecular clock in order to infer dating of speciations and other evolutionary events. Explicit modeling of substitution rates and divergence times makes formulation of informative prior distributions for branch lengths possible. Models with birth-death priors on tree branching and auto-correlated or iid substitution rates among lineages have been proposed, enabling simultaneous inference of substitution rates and divergence times. This problem has, however, mainly been analysed in the Markov chain Monte Carlo MCMC framework, an approach requiring computation times of hours or days when applied to large phylogenies. Results: We demonstrate that a hill-climbing maximum a posteriori MAP adaptation of the MCMC scheme results in considerable gain in computational efficiency. We demonstrate also that a novel dynamic programming DP algorithm for branch length factorization, useful both in the hill-climbing and in the MCMC setting, further reduces computation time.
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He talked a bit about how online dating is so popular in Sweden because Swedes are so reserved when it comes to meeting new people.
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